Consensus Rules in Variant Detection from Next-Generation Sequencing Data
نویسندگان
چکیده
منابع مشابه
Consensus Rules in Variant Detection from Next-Generation Sequencing Data
A critical step in detecting variants from next-generation sequencing data is post hoc filtering of putative variants called or predicted by computational tools. Here, we highlight four critical parameters that could enhance the accuracy of called single nucleotide variants and insertions/deletions: quality and deepness, refinement and improvement of initial mapping, allele/strand balance, and ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0038470